BenchSci is dedicated to exponentially increasing the speed and quality of life-saving research. We do so by empowering scientists with the world’s most advanced biomedical artificial intelligence to run more successful experiments. 

We started by addressing the antibody crisis to help scientists find the appropriate antibodies for their research. Next, we added RNAi and protein reagents to expand the scope and utility of our platform. Since then, we’ve been building on our technology, and developing new machine learning algorithms and data collection pipelines to further increase our coverage of reagents used in preclinical research. 

Today we’re excited to announce the addition of over 6.6M CRISPR reagents from top vendors to our AI-Assisted Reagent Selection platform!

Why CRISPR reagents?

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolution in gene-editing technology that allows scientists to engineer an organism’s genetic code with unprecedented ease and control. The CRISPR/Cas Nuclease (CRISPR associate protein) system is also an invaluable tool for understanding the etiology of diseases. 

Despite its growing importance in preclinical research, designing CRISPR experiments is not without its own challenges. Proteins are mentioned everywhere in the literature and a keyword search for “recombinant Cas9” will return thousands of results to sift through, many of which will not be relevant to your experimental context. Finding guide RNA (gRNA) sequences that target your gene of interest can be equally challenging, as traditional search platforms are not designed to search for gRNA nucleotide sequences. On top of all this, a target protein or gene may have multiple names and aliases, increasing the number of different search terms you need to investigate to conduct a comprehensive search. To help scientists overcome these challenges, we trained our AI to decode CRISPR experiments within published literature and combined it with our bioinformatics database so you can find the commercially available products and associated publication data most relevant to your experiments.

How can I access the CRISPR data?

You can find the two components of a CRISPR experiment, (the Cas nucleases that cleave the DNA and the guide RNAs responsible for targeting and recruiting Cas proteins) as new product types on BenchSci. 

New filters include:

Cas Specs:

  • Cas Type
  • Modification
  • Purity
  • Purification Method
  • Formulation
  • Vector Format
  • Promoter
  • Reporter
  • Selectable Marker

gRNA Specs:

  • Target Species
  • Cas Compatibility
  • Sequence
  • Target Location
  • Vector Format
  • Promoter
  • Reporter
  • Selectable Marker

 


These filters allow you to search through experimental data and product catalogs to find the CRISPR reagents most appropriate for your for knockdown, knockin, activation, and interference experiments. 

CRISPR Tech
Whether you’re looking for Cas9, Cas9 null or nickase, SaCas9, SaCas9 null, or Cas12a, you can find them all on BenchSci!

Screen Shot 2020-06-24 at 4.43.11 PM

Like RNAi experiments, we know scientists may opt for a made-to-order gRNA product rather than purchase an off-the-shelf nucleotide reagent. With this in mind, we expanded our sequence recognition technology to detect gRNA sequences that were used in the literature. 

CRISPR sequences
We’re proud to announce the addition of these reagents, and we’re constantly introducing updates to provide you with the best tool for your research. We’d love to hear about how you search for CRISPR reagents and how we can continue to help. Let us know in the comments below and subscribe to our blog to keep up with us! 

 

Written By:
Tim Fung

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